Wednesday, June 21, 2006

Timing and Cancer therapy

I just heard the 10.00 p.m. news on CNN- about a testimonial success treatment of giving cancer therapy when your normal body cells are dormant (sleeping) and cancer cells are active and dividing. Dr. Gypta gave the commentary.
I don't know why people should consider this such a unique technique. When I was director of the Winnipeg Clinic Research Institute Laboratory and was invited by the Horner drug company to give a talk at a symposium in Montreal in 1967 during Expo I spoke of the importance of "Analysis of stages of the cell cycle in Chemotherapy"
Analysis of stages means determining in a tumor as well as normal body tissue the proportion of cells in different stages of the cell cycle, i.e G1, S (DNA synthetic ) stage, G2 or post DNA synthetic, M or mitotic when the cells are undergoing cell division which can be visualized with an ordinary microscope and G0 or the stage of differentiation . With most cancer very few - if any cells enter the G0 stage, instead after cell division (M stage) they renter G1 and proceed through the S,G2 and M stages.
I had devised a method to do this analysis based on the combined techniques of DNA cytophotometry and cellular autoradiography using tritiated thymidine.
So you see Anderson Cooper the technique is not that new. Unfortunately in biology and other sciences, advances may sit undiscovered for years- like Mendel and Genetics. In my case I could not promote the technique because within a year after I gave the presentation the Board of Directors headed by Dr. P.H. Thorlakson dissolved the private research lab which was associated with the Winnipeg Clinic. In order to survive financially I had to abandon research and go into medical practice. The technique was published in the Can. Med. Assoc. J.

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