Saturday, May 14, 2005

Recruits for war on Cancer

To me if we are to win the war on cancer we must recruit to the cancer team scientists with a basic knowledge of biology- knowledge that I feel the current scientists are lacking or can't recall. If you don't believe me just test them for knowledge of the following:
In tumor biology-heteroploid transformation and heterokaryosis; stem line concept; analysis of stages of the cell cycle and its importance in chemotherapy
Cytogenetics/Genetics- importance of chiasma in the prevention of non disjunction and trisomy; gene location and changing phenotypic expression
Embryology- cytoclesis; importance of the presence of each primary germ layer in organogenesis. Do they know that if pancreatic anlage cells fail to make contact with embryonic mesoderm the organ will not develop. In the kidney such failure results in polycystic kidney.
Many of the organs of the body which have a high turn over - e.g. breast, lung, GI tract etc also have a high incidence of cancer. Could neoplastic transformation be nothing more than a defect in organogenesis
Maybe its time to send our generals with their forts and shining armour of sophisticated equipment back to universities to learn and/or recall Biology 101. Do teachers at these centers want to teach such a course?

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